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Electron Microscopy Public Image Archive

EMPIAR-13752
Rabbit ryanodine receptor type 1 complexed with FKBP12.6, calmodulin, dantrolene, ADP, 4-chloro-m-cresol, and caffeine [3928 multi-frame micrographs composed of 50 frames each in TIFF format]
Publication:

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB

bioRxiv (2024)

Related EMDB entry:
EMD-74306 EMD-74308 EMD-74404 EMD-74305 EMD-74403 EMD-74307 EMD-74436 EMD-74309
Deposited:
2026-07-01
Released:
2026-11-12
Last modified:
2026-11-12
Imageset size:
963.67 GB
Imageset DOI:
10.6019/EMPIAR-13752
Experimental metadata:
Download xml json
Contains:
  • micrographs - multiframe
Image Sets
1. Unaligned multi-frame micrographs of rabbit RyR1-FKBP12.6-CaM complex in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
3928
Image size:
(5760, 4092)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.83, 0.83)
Details:
Please use data/gain_reference_RyR1_DanADP.mrc with a Y-flip when importing into CryoSPARC. Particle images are located in data/particles. Particle positions, CTF estimations, and 3D alignments are described in the data/particles/RyR1_DanADP_particles.star text file. The exposure groups for individual exposures are logged in this .star file.
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Li F, Dong H, Tang S, Wang X, Zhang C, Ji C, Han R, Zhang F, Wan X. (2026)
Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene.
Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB. (2026)
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QwenCryoMarker: a universal post-processing framework for contamination-aware particle cleaning.
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