EMPIAR-13752 - Rabbit ryanodine receptor type 1 complexed with FKBP12.6, calmodulin, dantrolene, ADP, 4-chloro-m-cresol, and caffeine [3928 multi-frame micrographs composed of 50 frames each in TIFF format]

EMPIAR-13752

Rabbit ryanodine receptor type 1 complexed with FKBP12.6, calmodulin, dantrolene, ADP, 4-chloro-m-cresol, and caffeine [3928 multi-frame micrographs composed of 50 frames each in TIFF format]

Publication:

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB

bioRxiv (2024)

DOI: 10.1101/2024.10.21.619409

Related EMDB entry:

EMD-74306 EMD-74308 EMD-74404 EMD-74305 EMD-74403 EMD-74307 EMD-74436 EMD-74309

Deposited:

2026-07-01

Released:

2026-11-12

Last modified:

2026-11-12

Imageset size:

963.67 GB

Imageset DOI:

10.6019/EMPIAR-13752

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of rabbit RyR1-FKBP12.6-CaM complex in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3928

Image size:

(5760, 4092)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.83, 0.83)

Details:

Please use data/gain_reference_RyR1_DanADP.mrc with a Y-flip when importing into CryoSPARC. Particle images are located in data/particles. Particle positions, CTF estimations, and 3D alignments are described in the data/particles/RyR1_DanADP_particles.star text file. The exposure groups for individual exposures are logged in this .star file.

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Citations

CryoET-DDM: restoring high-fidelity signals in cryo-electron tomography via a data-driven diffusion model.

Wang X, Li F, Zhang C, Tang S, Jia Z, Hu B, Zhang F, Wan X. (2026)

CryoTriplane: triplane-based neural radiance field representation for high-resolution cryo-EM 3D homogeneous reconstruction.

Cheng Y, He B, Zeng Q, Zhang F, Han R. (2026)

CryoMV: Structure-Prior-Guided Modeling and Real-Particle Validation of Continuous Conformational Transitions in Cryo-EM

Li F, Dong H, Tang S, Wang X, Zhang C, Ji C, Han R, Zhang F, Wan X. (2026)

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene.

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB. (2026)

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph.

Watanabe R, Lee EB. (2026)

Post-acquisition super resolution for cryo-electron microscopy.

Burton Smith RN, Murata K. (2026)

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph

Watanabe R, Lee EB. (2026)

Agentic cryo-EM structure determination with CryoPilot

--- (2026)

Ligand-induced activation of RyR1 in native membranes.

Mikirtumov V, Golusik S, Huo R, Sprink T, Balyschew N, Yang W, Diebolder C, Yuan S, Kotecha A, Kudryashev M. (2026)

QwenCryoMarker: a universal post-processing framework for contamination-aware particle cleaning.

Sun Y, Zhao J, Xu N, Wang L, Ding W, Li M. (2026)

See all citations

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