EMPIAR-12808 - Cryo Electron Microscopy of hIAPP and rIAPP fibrils in different aggregation solutions [stack of 1200 particles in MRCS format]

EMPIAR-12808

Cryo Electron Microscopy of hIAPP and rIAPP fibrils in different aggregation solutions [stack of 1200 particles in MRCS format]

Publication:

Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides

Valli DV, Maj MM

Biochemistry (2025)

DOI: 10.1021/acs.biochem.5c00042

Related EMDB entry:

Deposited:

2025-05-15

Released:

2025-11-21

Last modified:

2025-11-21

Imageset size:

737.25 GB

Imageset DOI:

10.6019/EMPIAR-12808

Experimental metadata:

Download xml json

Contains:

picked particles - multiframe - processed

Image Sets

1. Extracted particle stacks of co-aggregates formed by human and rat IAPP (hIAPP and rIAPP) at varying ratios and in different buffer conditions.

Category:

picked particles - multiframe - processed

Image format:

MRCS

No. of images or tilt series:

1200

Image size:

(4096, 4096)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(None, None)

Details:

This dataset contains a randomized subset of RELION-extracted particle stacks of amyloid fibrils formed by co-aggregation of human and rat islet amyloid polypeptide (hIAPP and rIAPP) under various conditions. The dataset is organized into four top-level directories based on the aggregation buffer used, and each is further subdivided into four directories corresponding to different hIAPP:rIAPP ratios (1:0, 1:1, 1:4, and 1:20).

Files:

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Citations

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Yu C, Xu Z, Zeng Q, Wan X, El-Messiry H, Zhang F, Han R. (2026)

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Poudel B, Gyawali R, Dhakal A, Cheng J, Xu D. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

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Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

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Devarkar SC, Lomakin IB, Wang J, Grada A, Bunick CG. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

See all citations

Protein Data Bank Japan News

[2026-06-10]

333件のPDBエントリーが新たに公開されました。（2026-06-10付）