EMPIAR-13495 - Cryo electron microscopy of human SCFbxo22 in complex with protacs, neosubstrates and endogeneous substrates. [multiple data sets in MRC format]

EMPIAR-13495

Cryo electron microscopy of human SCFbxo22 in complex with protacs, neosubstrates and endogeneous substrates. [multiple data sets in MRC format]

Publication:

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22

Robertson KC, Amann SJ, Liu T, Funk AV, Wang X, Grishkovskaya I, Mehmood A, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL, Miao Y, Emanuele MJ, Haselbach D, James LI, Brown NG

Nature communications (2026)

PMID: 42026065

DOI: 10.1038/s41467-026-72235-9

Related EMDB entry:

EMD-57178 EMD-57179 EMD-57180

Deposited:

2026-03-17

Released:

2026-05-23

Last modified:

2026-05-23

Imageset size:

4.52 TB

Imageset DOI:

10.6019/EMPIAR-13495

Experimental metadata:

Download xml json

Contains:

micrographs - single frame

Image Sets

1. Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

48007

Image size:

(4096, 4096)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.951, 0.951)

Details:

Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088

Files:

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2. Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088 and BACH1

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

29805

Image size:

(4096, 4096)

Pixel type:

16 BIT FLOAT

Pixel spacing:

(0.951, 0.951)

Details:

Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10088 and BACH1

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

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3. Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10415667

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

30020

Image size:

(4096, 4096)

Pixel type:

16 BIT FLOAT

Pixel spacing:

(0.951, 0.951)

Details:

Motion corrected doseweighted micrographs of SCFBXO22 interacting with NSD2 via UNC10415667

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

rsync -av --files-from=(path-to-filelist) rsync://empiar.pdbj.org/empiar/archive (path-to-destination)

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Citations

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

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Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model.

Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

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Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

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ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)