EMPIAR-13364 - Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab [multiple data sets in TIFF and MRC formats]

EMPIAR-13364

Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab [multiple data sets in TIFF and MRC formats]

Publication:

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism

Sedzro JC, Photenhauer AL, Birkle F, Meze K, Mortenson A, Duckworth C, Wen PC, Kearns S, Cianfrocco MA, Tajkhorshid E, Ohi MD, Morrissey JH

Blood 146 (2025) 2833-2842

PMID: 40811856

DOI: 10.1182/blood.2025029430

Related EMDB entry:

EMD-71090 EMD-71095 EMD-71093

Deposited:

2025-07-30

Released:

2026-04-09

Last modified:

2026-04-09

Imageset size:

1.78 TB

Imageset DOI:

10.6019/EMPIAR-13364

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe
micrographs - single frame

Image Sets

1. Unaligned image stacks of nanodisc-embedded human tissue factor in complex with factor VIIa and XK1, a factor X mimetic, and 10H10 Fab

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

7132

Image size:

(5760, 4092)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.834, 0.834)

Details:

Unaligned micrographs in TIF format. Total accumulated dose of 50.2 electrons per square angstrom. Nominal magnification of 105,000kx corresponds to pixel spacing of 0.834 Angstrom per pixel.

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2. Gain reference for unaligned image stacks of nanodisc-embedded human tissue factor in complex with factor VIIa and XK1, a factor X mimetic, and 10H10 Fab

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

Image size:

(5760, 4092)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.834, 0.834)

Details:

Gain reference in .mrc format

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

rsync -av --files-from=(path-to-filelist) rsync://empiar.pdbj.org/empiar/archive (path-to-destination)

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Citations

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)