EMPIAR-13498 - Filament of D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments [13364 multi-frame micrographs composed of 2223 frames each in EER format]

EMPIAR-13498

Filament of D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments [13364 multi-frame micrographs composed of 2223 frames each in EER format]

Publication:

How short peptides disassemble tau fibrils in Alzheimer's disease

Hou K, Ge P, Sawaya MR, Lutter L, Dolinsky JL, Yang Y, Jiang YX, Boyer DR, Cheng X, Pi J, Zhang J, Lu J, Abskharon R, Yang S, Yu Z, Feigon J, Eisenberg DS

Nature 644 (2025) 1020-1027

PMID: 40634605

DOI: 10.1038/s41586-025-09244-z

Related EMDB entry:

EMD-44181

Deposited:

2026-04-16

Released:

2026-04-26

Last modified:

2026-04-26

Imageset size:

8.55 TB

Imageset DOI:

10.6019/EMPIAR-13498

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Filament of D-TLKIVWI, a D-peptide that disaggregates Alzheimer s Paired Helical Filaments

Category:

micrographs - multiframe

Image format:

EER

No. of images or tilt series:

13364

Image size:

(4096, 4096)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.94, 0.94)

Details:

Totally 2223 raw frames in EER format. Used first 2214 frames in 41 groups of 54 raw frames each. Dosage per group is 1.22 e-/A2.

Files:

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