EMPIAR-13222 - Cryo electron microscopy of modified human GABA(A) receptors reconstituted in lipid nanodiscs with the ligand GABOB [multiple data sets in MRCS format]

EMPIAR-13222

Cryo electron microscopy of modified human GABA(A) receptors reconstituted in lipid nanodiscs with the ligand GABOB [multiple data sets in MRCS format]

Publication:

Cryo-EM structures of ρ1 GABA(A) receptors with antagonist and agonist drugs

Fan C, Cowgill J, Howard RJ, Lindahl E

Nature Communications 16 (2025)

PMID: 40750757

DOI: 10.1038/s41467-025-61932-6

Related EMDB entry:

EMD-50714 EMD-50713

Deposited:

2026-01-19

Released:

2026-01-29

Last modified:

2026-01-29

Imageset size:

168.49 GB

Imageset DOI:

10.6019/EMPIAR-13222

Experimental metadata:

Download xml json

Contains:

picked particles - multiframe - processed

Image Sets

1. Images containing particles associated with the desensitized state

Category:

picked particles - multiframe - processed

Image format:

MRCS

No. of images or tilt series:

18711

Image size:

(420, 420)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.67, 1.0)

Details:

Particle positions in corresponding cs files

Files:

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2. Images containing particles associated with the partially locked state

Category:

picked particles - multiframe - processed

Image format:

MRCS

No. of images or tilt series:

21062

Image size:

(420, 420)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.67, 1.0)

Details:

Particle positions in corresponding cs files

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

rsync -av --files-from=(path-to-filelist) rsync://empiar.pdbj.org/empiar/archive (path-to-destination)

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Citations

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)