EMPIAR-13148 - Convergent and clonotype-specific mutations in the light chain drive affinity maturation of a public antibody targeting a cryptic epitope on S2 of sarbecoviruses [8135 multi-frame micrographs composed of 32 frames each in TIFF format]

EMPIAR-13148

Convergent and clonotype-specific mutations in the light chain drive affinity maturation of a public antibody targeting a cryptic epitope on S2 of sarbecoviruses [8135 multi-frame micrographs composed of 32 frames each in TIFF format]

Publication:

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope

Sapse IA, Cohn H, Yoo DK, Tong P, Clark JJ, Bozarth B, Chen Y, Srivastava K, Singh G, Krammer F, Simon V, Wesemann DR, Bajic G, Coelho CH

Cell reports 44 (2025)

PMID: 40803328

DOI: 10.1016/j.celrep.2025.116122

Related EMDB entry:

EMD-48507

Deposited:

2025-03-04

Released:

2026-03-19

Last modified:

2026-03-19

Imageset size:

1.45 TB

Imageset DOI:

10.6019/EMPIAR-13148

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. movies of SARS-CoV2 S2-M15 Fab Complex

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

8135

Image size:

(None, None)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.826, 0.826)

Details:

---

Files:

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Citations

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He L, Bartesaghi A. (2026)

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Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

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Dual site targeting of the bacterial 70S ribosome by tetracyclines.

Devarkar SC, Lomakin IB, Wang J, Grada A, Bunick CG. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

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Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

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Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)