EMPIAR-14006 - 2026 CAHRA Challenge 2) Conformational Heterogeneity [stack of 1753470 particles in MRCS format]

EMPIAR-14006

2026 CAHRA Challenge 2) Conformational Heterogeneity [stack of 1753470 particles in MRCS format]

Publication:

The CAHRA Challenge: A Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms

Feathers JR, Zhong ED, Heeter RC, Woollard G, Hanson SM, Cossio P, Greer JAT, Burnley T

bioRxiv (2026)

DOI: 10.64898/2026.09.15.751515

Related EMDB entry:

Deposited:

2026-09-09

Released:

2026-10-06

Last modified:

2026-10-06

Imageset size:

215.38 GB

Imageset DOI:

10.6019/EMPIAR-14006

Experimental metadata:

Download xml json

Contains:

picked particles - single frame - unprocessed

Image Sets

1. Simulated CAHRA conformational heterogeneity challenge particle images

Category:

picked particles - single frame - unprocessed

Image format:

MRCS

No. of images or tilt series:

1753470

Image size:

(256, 256)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(1.0, 1.0)

Details:

Simulated CAHRA conformational heterogeneity challenge particle images with ground truth conformations, poses, and defocus values provided in particles_GT_confs.star. Images were simulated from atomic models provided in pdb and mmcif format

Files:

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Citations

Post-acquisition super resolution for cryo-electron microscopy.

Burton Smith RN, Murata K. (2026)

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph

Watanabe R, Lee EB. (2026)

Ligand-induced activation of RyR1 in native membranes.

Mikirtumov V, Golusik S, Huo R, Sprink T, Balyschew N, Yang W, Diebolder C, Yuan S, Kotecha A, Kudryashev M. (2026)

QwenCryoMarker: a universal post-processing framework for contamination-aware particle cleaning.

Sun Y, Zhao J, Xu N, Wang L, Ding W, Li M. (2026)

CryoMV: Structure-Prior-Guided Modeling and Real-Particle Validation of Continuous Conformational Transitions in Cryo-EM

Li F, Dong H, Tang S, Wang X, Zhang C, Ji C, Han R, Zhang F, Wan X. (2026)

An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM.

Marchán Torres D, Conesa P, Garcia A, Iceta M, Broche L, Gragera M, Linares R, Kwong HS, Chichón FJ, Svensson O, Arranz R, Effantin G, Kandiah E, Carazo JM, Sorzano COS. (2026)

AlignPCA-2D: PCA-reduced Euclidean vector alignment for 2D classification in cryo-EM.

Ramírez-Aportela E, Zarrabeitia OL, Fonseca YC, Ceska T, Subramaniam S, Carazo JM, Sorzano COS. (2026)

Helical reconstruction of amyloids in cryoSPARC.

Schaefer JH, O'Neill RT, Donnelly JP, Powers ET, Kelly JW, Lander GC. (2026)

A variational framework with composite sparse regularization for cryo-electron tomography reconstruction.

Yu C, Xu Z, Zeng Q, Wan X, El-Messiry H, Zhang F, Han R. (2026)

CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs.

Poudel B, Gyawali R, Dhakal A, Cheng J, Xu D. (2026)

See all citations

Protein Data Bank Japan News

[2026-10-06]

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