EMPIAR-13184 - Cryo-EM structure of alpha-synuclein fibrils formed in artificial cerebrospinal fluid (aCSF) [3510 multi-frame micrographs composed of 317 frames each in EER format]

EMPIAR-13184

Cryo-EM structure of alpha-synuclein fibrils formed in artificial cerebrospinal fluid (aCSF) [3510 multi-frame micrographs composed of 317 frames each in EER format]

Publication:

Formation of Condition-Dependent Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Sniečkutė R, Šulskis D, Jocytė A, Venclovaitė U, Tamulytė R, Žiaunys M, Smirnovas V, Sakalauskas A

Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)

PMID: 41262012

DOI: 10.1002/advs.202505228

Related EMDB entry:

EMD-52833

Deposited:

2024-11-11

Released:

2026-01-20

Last modified:

2026-01-20

Imageset size:

2.72 TB

Imageset DOI:

10.6019/EMPIAR-13184

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unalligned multiframe micrographs of alpha-synuclein fibrils formed in aCSF

Category:

micrographs - multiframe

Image format:

EER

No. of images or tilt series:

3510

Image size:

(4096, 4096)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(0.754, 0.754)

Details:

EER files from a Falcon 4i detector. Raw micrographs, not motion corrected and picked particles.

Files:

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Citations

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Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

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Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

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Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)