EMPIAR-12968 - Time-resolved cryo-EM dataset of insulin degrading enzyme in the presence of a 5x molar excess of insulin with a 123 ms freeze time [10932 multi-frame micrographs composed of 50 frames each in TIFF format]

EMPIAR-12968

Time-resolved cryo-EM dataset of insulin degrading enzyme in the presence of a 5x molar excess of insulin with a 123 ms freeze time [10932 multi-frame micrographs composed of 50 frames each in TIFF format]

Publication:

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

Mancl JM, Tang WJ

eLife (---)

DOI: 10.7554/eLife.105761.1

Related EMDB entry:

Deposited:

2025-09-09

Released:

2026-04-27

Last modified:

2026-04-27

Imageset size:

5.28 TB

Imageset DOI:

10.6019/EMPIAR-12968

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Micrographs of IDE in the presence of a 5x molar excess of insulin rapidly mixed and frozen at 123 ms

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

10932

Image size:

(None, None)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

---

Files:

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Citations

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

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Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)