EMPIAR-12968 - Time-resolved cryo-EM dataset of insulin degrading enzyme in the presence of a 5x molar excess of insulin with a 123 ms freeze time [10932 multi-frame micrographs composed of 50 frames each in TIFF format]

EMPIAR-12968

Time-resolved cryo-EM dataset of insulin degrading enzyme in the presence of a 5x molar excess of insulin with a 123 ms freeze time [10932 multi-frame micrographs composed of 50 frames each in TIFF format]

Publication:

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

Mancl JM, Tang WJ

eLife (---)

DOI: 10.7554/eLife.105761.1

Related EMDB entry:

Deposited:

2025-09-09

Released:

2026-04-27

Last modified:

2026-04-27

Imageset size:

5.28 TB

Imageset DOI:

10.6019/EMPIAR-12968

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Micrographs of IDE in the presence of a 5x molar excess of insulin rapidly mixed and frozen at 123 ms

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

10932

Image size:

(None, None)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

---

Files:

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Citations

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Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

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Jones HN, Deshmukh A, Pande K. (2026)

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Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)