EMPIAR-11745 - In vitro TDP-43 amyloid fibrils [1641 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-11745

In vitro TDP-43 amyloid fibrils [1641 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils

Sharma K, Stockert F, Shenoy J, Berbon M, Abdul-Shukkoor MB, Habenstein B, Loquet A, Schmidt M, Fändrich M

Nature communications 15 (2024)

PMID: 38212334

DOI: 10.1038/s41467-023-44489-0

Related EMDB entry:

EMD-18717 EMD-18715 EMD-18716

Deposited:

2023-08-03

Released:

2024-06-04

Last modified:

2024-06-04

Imageset size:

280.11 GB

Imageset DOI:

10.6019/EMPIAR-11745

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of TDP-43 amyloid fibrils

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

1641

Image size:

(3838, 3710)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(1.04, 1.04)

Details:

The gain reference (/data/EM_data/CountRef_0001.dm4) is not applied to the raw micrographs. The NOTES.txt file contains EM information (copied below). The coordinates are divided into Morphology-1 (/data/Coordinatesfiles_Morphology1) and Morphology-2 (/data/Coordinatesfiles_Morphology2).

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
NOTES.txt

EMBL Heidelberg
Krios1 Quantum-K2
Cs 2.7
300kV EFTEM nanpprobe
x130k spot 8 beam size 650nm
c2=50 objective_aperture=100

GIF-K2 counting
10s exposure 40 frames
total dose at the sample 52.08e/A2
1 pixel = 1.04A
dose rate ~3-4 e/pix/s

defocus range -1.2 to -2.5

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Protein Data Bank Japan News

[2026-06-24]

379件のPDBエントリーが新たに公開されました。（2026-06-24付）