EMPIAR-11711 - Cryo-EM micrographs of human DNA polymerase θ helicase domain bound to inhibitor AB25583 [4500 multi-frame micrographs composed of 2051 frames each in EER format]

EMPIAR-11711

Cryo-EM micrographs of human DNA polymerase θ helicase domain bound to inhibitor AB25583 [4500 multi-frame micrographs composed of 2051 frames each in EER format]

Publication:

Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM

Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT

Nature communications 15 (2024)

PMID: 39143110

DOI: 10.1038/s41467-024-51351-4

Related EMDB entry:

EMD-44765 EMD-44766

Deposited:

2023-09-18

Released:

2024-08-29

Last modified:

2024-08-29

Imageset size:

4.92 TB

Imageset DOI:

10.6019/EMPIAR-11711

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of human DNA polymerase θ helicase domain bound to inhibitor AB25583

Category:

micrographs - multiframe

Image format:

EER

No. of images or tilt series:

4500

Image size:

(4096, 4096)

Pixel type:

BIT

Pixel spacing:

(0.92, 0.92)

Details:

We recommend dividing the total frames into 40 frame movies for motion correction. The gain reference image is in the root folder, it does not need to be flipped or rotated.

Files:

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Citations

A variational framework with composite sparse regularization for cryo-electron tomography reconstruction.

Yu C, Xu Z, Zeng Q, Wan X, El-Messiry H, Zhang F, Han R. (2026)

CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs.

Poudel B, Gyawali R, Dhakal A, Cheng J, Xu D. (2026)

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model.

Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Dual site targeting of the bacterial 70S ribosome by tetracyclines.

Devarkar SC, Lomakin IB, Wang J, Grada A, Bunick CG. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

See all citations

Protein Data Bank Japan News

[2026-06-17]

324件のPDBエントリーが新たに公開されました。（2026-06-17付）