EMPIAR-10166 - human 26S proteasome bound to the chemotherapeutic Oprozomib [stack of 238631 particles in MRCS format]

EMPIAR-10166

human 26S proteasome bound to the chemotherapeutic Oprozomib [stack of 238631 particles in MRCS format]

Publication:

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

Haselbach D, Schrader J, Lambrecht F, Henneberg F, Chari A, Stark H

Nature communications 8 (2017) 15578-15586

PMID: 28541292

DOI: 10.1038/ncomms15578

Related EMDB entry:

EMD-4146

Deposited:

2018-03-21

Released:

2018-03-21

Last modified:

2018-03-21

Imageset size:

100.48 GB

Imageset DOI:

10.6019/EMPIAR-10166

Experimental metadata:

Download xml json

Contains:

picked particles - single frame - processed

Image Sets

1. Particle stack of aligned, summed and dose weighted particle images from the human 26S proteasome bound to oprozomib.

Category:

picked particles - single frame - processed

Image format:

MRCS

No. of images or tilt series:

238631

Image size:

(336, 336)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(1.27, 1.27)

Details:

Particle stack of aligned, summed and dose weighted particle images from the human 26S proteasome bound to oprozomib. Total dose 40 electrons per Angstroem squared. Images are already inverted and normalized.

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Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

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