EMPIAR-14073 - Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with (R)-BPO-27 and ATP/Mg [7696 micrographs in MRC format]

EMPIAR-14073

Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with (R)-BPO-27 and ATP/Mg [7696 micrographs in MRC format]

Publication:

Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism

Young PG, Fiedorczuk K, Chen J

Nature communications 16 (2025)

PMID: 40750590

DOI: 10.1038/s41467-025-62199-7

Related EMDB entry:

EMD-48717

Deposited:

2026-10-20

Released:

2026-10-26

Last modified:

2026-10-26

Imageset size:

676.37 GB

Imageset DOI:

10.6019/EMPIAR-14073

Experimental metadata:

Download xml json

Contains:

micrographs - single frame

Image Sets

1. Motion-corrected micrographs of phosphorylated human CFTR (E1371Q) in complex with (R)-BPO-27 and ATP-Mg

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

7696

Image size:

(4096, 5760)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.676, 0.676)

Details:

The micrographs are the average of images taken with a total dose of 65.6 electrons per square-angstrom.

Files:

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