EMPIAR-13753 - Rabbit ryanodine receptor type 1 complexed with FKBP12.6 and calmodulin in the presence of physiological concentrations of ATP, ADP, and Mg2+ [3556 multi-frame micrographs composed of 50 frames each in TIFF format]

EMPIAR-13753

Rabbit ryanodine receptor type 1 complexed with FKBP12.6 and calmodulin in the presence of physiological concentrations of ATP, ADP, and Mg2+ [3556 multi-frame micrographs composed of 50 frames each in TIFF format]

Publication:

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB

bioRxiv (2024)

DOI: 10.1101/2024.10.21.619409

Related EMDB entry:

EMD-74352 EMD-74354 EMD-74361 EMD-74353 EMD-74348 EMD-74438 EMD-74362 EMD-74349 EMD-74355

Deposited:

2026-07-01

Released:

2026-11-12

Last modified:

2026-11-12

Imageset size:

921.76 GB

Imageset DOI:

10.6019/EMPIAR-13753

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of rabbit RyR1-FKBP12.6-CaM complex in the presence of physiological concentrations of ATP, ADP, and Mg2+

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3556

Image size:

(5760, 4092)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.83, 0.83)

Details:

Please use data/movies/gain_reference_RyR1_physiological.mrc with a Y-flip when importing into CryoSPARC. Particle images are located in data/particles. Particle positions, CTF estimations, and 3D alignments are described in the data/particles/RyR1_Physiological_particles.star text file. The exposure groups for individual exposures are logged in this .star file.

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Citations

CryoET-DDM: restoring high-fidelity signals in cryo-electron tomography via a data-driven diffusion model.

Wang X, Li F, Zhang C, Tang S, Jia Z, Hu B, Zhang F, Wan X. (2026)

CryoTriplane: triplane-based neural radiance field representation for high-resolution cryo-EM 3D homogeneous reconstruction.

Cheng Y, He B, Zeng Q, Zhang F, Han R. (2026)

CryoMV: Structure-Prior-Guided Modeling and Real-Particle Validation of Continuous Conformational Transitions in Cryo-EM

Li F, Dong H, Tang S, Wang X, Zhang C, Ji C, Han R, Zhang F, Wan X. (2026)

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene.

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB. (2026)

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph.

Watanabe R, Lee EB. (2026)

Post-acquisition super resolution for cryo-electron microscopy.

Burton Smith RN, Murata K. (2026)

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph

Watanabe R, Lee EB. (2026)

Agentic cryo-EM structure determination with CryoPilot

--- (2026)

Ligand-induced activation of RyR1 in native membranes.

Mikirtumov V, Golusik S, Huo R, Sprink T, Balyschew N, Yang W, Diebolder C, Yuan S, Kotecha A, Kudryashev M. (2026)

QwenCryoMarker: a universal post-processing framework for contamination-aware particle cleaning.

Sun Y, Zhao J, Xu N, Wang L, Ding W, Li M. (2026)

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