EMPIAR-13697 - Single-Particle Cryo-EM of a Nucleosome Containing a Single-Strand Break at SHL −2.8 Bound to the Human PARP2 WGR Domain [3768 multi-frame micrographs composed of 40 frames each in EER format]

EMPIAR-13697

Single-Particle Cryo-EM of a Nucleosome Containing a Single-Strand Break at SHL −2.8 Bound to the Human PARP2 WGR Domain [3768 multi-frame micrographs composed of 40 frames each in EER format]

Publication:

High-Yield Production of Modified DNA Enables Structural Analysis of PARP2 Recognition of Nucleosomal Single-Strand Breaks

Jayathilake C, Mewhinney CE, Gregory-Lott ER, Virk RK, Nair R, Yang J, Cho E, Day AG, Taylor DJ, Kim TH

Journal of molecular biology 438 (2026)

PMID: 41819421

DOI: 10.1016/j.jmb.2026.169753

Related EMDB entry:

EMD-75074 EMD-74562 EMD-75079 EMD-75080 EMD-74561 EMD-75075

Deposited:

2026-06-17

Released:

2026-06-29

Last modified:

2026-06-29

Imageset size:

2.18 TB

Imageset DOI:

10.6019/EMPIAR-13697

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of a Nucleosome Containing a Single-Strand Break at SHL −2.8 Bound to the Human PARP2 WGR Domain

Category:

micrographs - multiframe

Image format:

EER

No. of images or tilt series:

3768

Image size:

(4096, 4096)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(0.9105, 0.9105)

Details:

---

Files:

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Citations

A variational framework with composite sparse regularization for cryo-electron tomography reconstruction.

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prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

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CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

Dual site targeting of the bacterial 70S ribosome by tetracyclines.

Devarkar SC, Lomakin IB, Wang J, Grada A, Bunick CG. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

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[2026-06-24]

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