EMPIAR-13098 - High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib [13011 multi-frame micrographs composed of 36 frames each in TIFF format]

EMPIAR-13098

High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib [13011 multi-frame micrographs composed of 36 frames each in TIFF format]

Publication:

High-resolution cryo-EM structures of small protein–ligand complexes near the theoretical size limit

Park K, Yoo Y, Jeon H, Choi K, Kwon E, Lim H, Kim DY, No KT

bioRxiv (2025)

DOI: 10.1101/2025.06.30.662489

Related EMDB entry:

EMD-68616

Deposited:

2025-11-08

Released:

2026-05-05

Last modified:

2026-05-05

Imageset size:

1.76 TB

Imageset DOI:

10.6019/EMPIAR-13098

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. unaligned multi-frame micrographs of human Polo-like kinase 1 in complex with onvansertib

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

13011

Image size:

(4096, 4096)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

---

Files:

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Citations

AlignPCA-2D: PCA-reduced Euclidean vector alignment for 2D classification in cryo-EM.

Ramírez-Aportela E, Zarrabeitia OL, Fonseca YC, Ceska T, Subramaniam S, Carazo JM, Sorzano COS. (2026)

A variational framework with composite sparse regularization for cryo-electron tomography reconstruction.

Yu C, Xu Z, Zeng Q, Wan X, El-Messiry H, Zhang F, Han R. (2026)

Helical reconstruction of amyloids in cryoSPARC.

Schaefer JH, O'Neill RT, Donnelly JP, Powers ET, Kelly JW, Lander GC. (2026)

An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM.

Marchán Torres D, Conesa P, Garcia A, Iceta M, Broche L, Gragera M, Linares R, Kwong HS, Chichón FJ, Svensson O, Arranz R, Effantin G, Kandiah E, Carazo JM, Sorzano COS. (2026)

CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs.

Poudel B, Gyawali R, Dhakal A, Cheng J, Xu D. (2026)

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model.

Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

CryoWriter: a robotic solution for improved Cryo-EM grid preparation.

Kv C, Ekundayo B, Di Fabrizio M, Mohammed I, Radecke J, Stahlberg H, Kube M. (2026)