EMPIAR-13098 - High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib [13011 multi-frame micrographs composed of 36 frames each in TIFF format]

EMPIAR-13098

High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib [13011 multi-frame micrographs composed of 36 frames each in TIFF format]

Publication:

High-resolution cryo-EM structures of small protein–ligand complexes near the theoretical size limit

Park K, Yoo Y, Jeon H, Choi K, Kwon E, Lim H, Kim DY, No KT

bioRxiv (2025)

DOI: 10.1101/2025.06.30.662489

Related EMDB entry:

EMD-68616

Deposited:

2025-11-08

Released:

2026-05-05

Last modified:

2026-05-05

Imageset size:

1.76 TB

Imageset DOI:

10.6019/EMPIAR-13098

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. unaligned multi-frame micrographs of human Polo-like kinase 1 in complex with onvansertib

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

13011

Image size:

(4096, 4096)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

---

Files:

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Citations

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)