EMPIAR-12870 - Patient derived AD PHF with PET Ligand MK-6240 [multiple data sets in TIFF format]

EMPIAR-12870

Patient derived AD PHF with PET Ligand MK-6240 [multiple data sets in TIFF format]

Publication:

Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240

Kunach P, Vaquer-Alicea J, Smith MS, Monistrol J, Hopewell R, Moquin L, Therriault J, Tissot C, Rahmouni N, Massarweh G, Soucy JP, Guiot MC, Shoichet BK, Rosa-Neto P, Diamond MI, Shahmoradian SH

Nature communications 15 (2024) 8497-8497

PMID: 39353896

DOI: 10.1038/s41467-024-52265-x

Related EMDB entry:

EMD-42463

Deposited:

2025-01-03

Released:

2026-03-02

Last modified:

2026-03-02

Imageset size:

7.39 TB

Imageset DOI:

10.6019/EMPIAR-12870

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame movies of tau filaments from sporadic AD complexed to PET ligand MK-6240 (10uM)

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3978

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.415, 0.415)

Details:

dose per frame: ~1.04 e-/A2/frame;

Files:

This entry cannot be downloaded from PDBj.

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2. Unaligned multi-frame movies of tau filaments from sporadic AD incubated with pan-Amyloid dye Thioflavin T (10uM)

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

4195

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.415, 0.415)

Details:

dose per frame: ~1.04 e-/A2/frame;

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

rsync -av --files-from=(path-to-filelist) rsync://empiar.pdbj.org/empiar/archive (path-to-destination)

3. Unaligned multi-frame movies of tau filaments from sporadic AD incubated with 3% DMSO

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3842

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.415, 0.415)

Details:

dose per frame: ~1.0 e-/A2/frame;

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

rsync -av --files-from=(path-to-filelist) rsync://empiar.pdbj.org/empiar/archive (path-to-destination)

4. Unaligned multi-frame movies of tau filaments from sporadic AD incubated native condition

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

5360

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.415, 0.415)

Details:

dose per frame: ~1.04 e-/A2/frame;

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

It is possible to download files by specifying the file list with rsync command, etc.

rsync -av --files-from=(path-to-filelist) rsync://empiar.pdbj.org/empiar/archive (path-to-destination)

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Citations

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CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Krentzel D, Elphick M, Domart MC, Peddie CJ, Laine RF, Shand C, Henriques R, Collinson LM, Jones ML. (2025)

CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy.

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