EMPIAR-12553 - Integrin alpha-5 beta-1 in complex with MINT1526a Fab [multiple data sets in TIFF, MRC and MRCS formats]

EMPIAR-12553

Integrin alpha-5 beta-1 in complex with MINT1526a Fab [multiple data sets in TIFF, MRC and MRCS formats]

Publication:

Structural and functional characterization of integrin α5-targeting antibodies for anti-angiogenic therapy

Nguyen AN, Heim JBH, Cordara GC, Chan MCC, Johannesen HJ, Charlesworth CC, Li ML, Azumaya CMA, Madden BM, Krengel UK, Campbell MGC, Meves AM

bioRxiv (---)

DOI: 10.1101/2025.01.08.631572

Related EMDB entry:

EMD-44387

Deposited:

2023-11-07

Released:

2025-12-01

Last modified:

2025-12-01

Imageset size:

3.06 TB

Imageset DOI:

10.6019/EMPIAR-12553

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe
micrographs - single frame
picked particles - single frame - processed

Image Sets

1. Unaligned Frames of integrin a5b1 in complex with MINT1526a antibody fab fragment

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3079

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.561, 0.561)

Details:

Tiff files containing the raw 99 movie frame (accumulating approximately 50 electron squared angstrom in a 6 second exposure.

Files:

This entry cannot be downloaded from PDBj.

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2. Motion corrected frames of integrin a5b1 in complex with MINT1526a antibody fab fragment

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

3079

Image size:

(5760, 4092)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(1.122, 1.122)

Details:

Motion Corrected micrographs using MotionCorr2.

Files:

This entry cannot be downloaded from PDBj.

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3. Movie Gain Refs

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

Image size:

(11520, 8184)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.556, 0.556)

Details:

Gain reference for movie collection in DM4 and MRC format

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

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4. Polished particle of integrin a5b1 in complex with MINT1526a antibody fab fragment

Category:

picked particles - single frame - processed

Image format:

MRCS

No. of images or tilt series:

342608

Image size:

(352, 352)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(1.122, 1.122)

Details:

Polished particles from RELION using particle polishing

Files:

This entry cannot be downloaded from PDBj.

Archives and downloads the selected files into an uncompressed zip file.

We recommend using rsync, aspera, globus, etc.

Download a list of selected files.

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Citations

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Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model.

Kong L, Zottig X, Elferich J, Grigorieff N. (2026)

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Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

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Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

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Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)