EMPIAR-12553 - Integrin alpha-5 beta-1 in complex with MINT1526a Fab [multiple data sets in TIFF, MRC and MRCS formats]

EMPIAR-12553

Integrin alpha-5 beta-1 in complex with MINT1526a Fab [multiple data sets in TIFF, MRC and MRCS formats]

Publication:

Structural and functional characterization of integrin α5-targeting antibodies for anti-angiogenic therapy

Nguyen AN, Heim JBH, Cordara GC, Chan MCC, Johannesen HJ, Charlesworth CC, Li ML, Azumaya CMA, Madden BM, Krengel UK, Campbell MGC, Meves AM

bioRxiv (---)

DOI: 10.1101/2025.01.08.631572

Related EMDB entry:

EMD-44387

Deposited:

2023-11-07

Released:

2025-12-01

Last modified:

2025-12-01

Imageset size:

3.06 TB

Imageset DOI:

10.6019/EMPIAR-12553

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe
micrographs - single frame
picked particles - single frame - processed

Image Sets

1. Unaligned Frames of integrin a5b1 in complex with MINT1526a antibody fab fragment

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3079

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.561, 0.561)

Details:

Tiff files containing the raw 99 movie frame (accumulating approximately 50 electron squared angstrom in a 6 second exposure.

Files:

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2. Motion corrected frames of integrin a5b1 in complex with MINT1526a antibody fab fragment

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

3079

Image size:

(5760, 4092)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(1.122, 1.122)

Details:

Motion Corrected micrographs using MotionCorr2.

Files:

This entry cannot be downloaded from PDBj.

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3. Movie Gain Refs

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

Image size:

(11520, 8184)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.556, 0.556)

Details:

Gain reference for movie collection in DM4 and MRC format

Files:

This entry cannot be downloaded from PDBj.

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4. Polished particle of integrin a5b1 in complex with MINT1526a antibody fab fragment

Category:

picked particles - single frame - processed

Image format:

MRCS

No. of images or tilt series:

342608

Image size:

(352, 352)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(1.122, 1.122)

Details:

Polished particles from RELION using particle polishing

Files:

This entry cannot be downloaded from PDBj.

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Citations

GTpick: A deep neural network for Cryo-EM particle detection.

Ni S, Yang C, Liu Y, Zhang Y, Shi Y, Qian A, Kong R, Chang S. (2025)

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Kim K, Li H, Clarke OB. (2025)

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Krentzel D, Elphick M, Domart MC, Peddie CJ, Laine RF, Shand C, Henriques R, Collinson LM, Jones ML. (2025)

PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning.

Costa-Gomes B, Greer J, Juraschko N, Parkhurst J, Mirecka J, Famili M, Rangel-Smith C, Strickson O, Lowe A, Basham M, Burnley T. (2025)

CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy.

Arora S, Pan SH, Kumar S, Singh SK, Chauhan U, Alhalabi W, Arya V, Alsulami BS, Hsu CH, Chui KT, Gupta BB. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

Localization of macromolecules in crowded cellular cryo-electron tomograms from extremely sparse labels.

Uddin MR, Ahmed AY, Tabib HMS, Tahmid MT, Alam MZU, Freyberg Z, Xu M. (2025)

Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase.

Wu K, Wang Z, Yao D, Li S, Wang X, Zhang Y, Cao M, Shen Y, Xing S, Wu J, Lei M, Lan P. (2025)

Conserved hydrophilic checkpoints tune FocA-mediated formate:H<sup>+</sup> symport.

Tüting C, Janson K, Kammel M, Ihling C, Lorenz J, Kyrilis FL, Hamdi F, Erdmann C, Sinz A, Sawers RG, Kastritis PL. (2025)

Icecream: High-Fidelity Equivariant Cryo-Electron Tomography

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2025)

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