EMPIAR-11986 - cryoEM structure of Gq-coupled MRGPRX4 with fospropofol bound [6108 micrographs in MRC format]

EMPIAR-11986

cryoEM structure of Gq-coupled MRGPRX4 with fospropofol bound [6108 micrographs in MRC format]

Publication:

MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model

Chien DC, Limjunyawong N, Cao C, Meixiong J, Peng Q, Ho CY, Fay JF, Roth BL, Dong X

Science translational medicine 16 (2024)

PMID: 38718132

DOI: 10.1126/scitranslmed.adk8198

Related EMDB entry:

EMD-39542

Deposited:

2024-03-21

Released:

2025-04-24

Last modified:

2025-04-24

Imageset size:

536.32 GB

Imageset DOI:

10.6019/EMPIAR-11986

Experimental metadata:

Download xml json

Contains:

micrographs - single frame

Image Sets

1. aligned multi-frame micrographs

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

6108

Image size:

(5760, 4092)

Pixel type:

UNSIGNED 32 BIT INTEGER

Pixel spacing:

(None, None)

Details:

---

Files:

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Citations

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)