EMPIAR-11870 - Single particle Cryo EM of the C-terminal half LRRK2 G2019S mutant bound to GZD-824 [7988 multi-frame micrographs composed of 40 frames each in EER format]

EMPIAR-11870

Single particle Cryo EM of the C-terminal half LRRK2 G2019S mutant bound to GZD-824 [7988 multi-frame micrographs composed of 40 frames each in EER format]

Publication:

Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures

Sanz Murillo M, Villagran Suarez A, Dederer V, Chatterjee D, Alegrio Louro J, Knapp S, Mathea S, Leschziner AE

Science advances 9 (2023)

PMID: 38039358

DOI: 10.1126/sciadv.adk6191

Related EMDB entry:

EMD-41728

Deposited:

2024-01-24

Released:

2024-02-09

Last modified:

2024-02-09

Imageset size:

6.99 TB

Imageset DOI:

10.6019/EMPIAR-11870

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multiframe micrographs

Category:

micrographs - multiframe

Image format:

EER

No. of images or tilt series:

7988

Image size:

(None, None)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(0.935, 0.935)

Details:

Contains data collected from 1 grids on different days, 03/23/2023 and 03/27/2023

Files:

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Citations

Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase.

Ito F, Alvarez-Cabrera AL, Liu S, Yang H, Shiriaeva A, Zhou ZH, Chen XS. (2023)

The 2023 Nucleic Acids Research Database Issue and the online molecular biology database collection.

Rigden DJ, Fernández XM. (2023)

EMPIAR: the Electron Microscopy Public Image Archive.

Iudin A, Korir PK, Somasundharam S, Weyand S, Cattavitello C, Fonseca N, Salih O, Kleywegt GJ, Patwardhan A. (2023)

CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM.

Serra Lleti JM, Steyer AM, Schieber NL, Neumann B, Tischer C, Hilsenstein V, Holtstrom M, Unrau D, Kirmse R, Lucocq JM, Pepperkok R, Schwab Y. (2023)

Structure of a RecT/Redβ family recombinase in complex with a duplex intermediate of DNA annealing.

Caldwell BJ, Norris AS, Karbowski CF, Wiegand AM, Wysocki VH, Bell CE. (2022)

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