EMPIAR-11509 - In-tissue cryo electron tomography of App^NL-G-F amyloid plaques [23 tilt series in MRC format]

EMPIAR-11509

In-tissue cryo electron tomography of App^NL-G-F amyloid plaques [23 tilt series in MRC format]

Publication:

The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain

Leistner C, Wilkinson M, Burgess A, Lovatt M, Goodbody S, Xu Y, Deuchars S, Radford SE, Ranson NA, Frank RAW

Nature communications 14 (2023)

PMID: 37198197

DOI: 10.1038/s41467-023-38495-5

Related EMDB entry:

EMD-18301 EMD-16018

Deposited:

2023-04-14

Released:

2023-09-22

Last modified:

2023-09-22

Imageset size:

38.00 GB

Imageset DOI:

10.6019/EMPIAR-11509

Experimental metadata:

Download xml json

Contains:

tilt series

Image Sets

1. Summed, unaligned tilt series

Category:

tilt series

Image format:

MRC

No. of images or tilt series:

Image size:

(3710, 3838)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(3.421, 3.421)

Details:

Summed, unaligned tilt series from 23 tomograms, -60 to +60˚, 2˚ increments, 85.8˚ microscope rotation angle (hand unknown), ~1 e-/Å2 dose per tilt.
Corresponding CryoCLEM images are also supplied

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Citations

prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation.

He L, Bartesaghi A. (2026)

CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.

Deng Y, Wang S, Xiang M, Li Y, Zhuo L, Cao D, Fu X, Zou Q. (2026)

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank.

Fonseca N, Duraisamy AK, Wang Z, Somasundharam S, Tayebinia M, de Oliveira LC, Ma M, Turner J, Patwardhan A, Kleywegt GJ, Hartley M, Morris KL. (2026)

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Gyawali R, Dhakal A, Wang L, Cheng J. (2026)

Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements.

Jones HN, Deshmukh A, Pande K. (2026)

CryoGS: High-Quality Cryo-EM Homogeneous Reconstruction by Gaussian Splatting

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2026)

Point cloud deformation modeling for particle selection following cryo-EM 2D classification.

Wang X, Mo Z, Li F, Zhang F, Wan X. (2026)

ICECREAM: high-fidelity equivariant cryo-electron tomography.

Kishore V, Debarnot V, Righetto RD, Engel BD, Dokmanić I. (2026)

CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.

Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA. (2025)