EMPIAR-11509 - In-tissue cryo electron tomography of App^NL-G-F amyloid plaques [23 tilt series in MRC format]

EMPIAR-11509

In-tissue cryo electron tomography of App^NL-G-F amyloid plaques [23 tilt series in MRC format]

Publication:

The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain

Leistner C, Wilkinson M, Burgess A, Lovatt M, Goodbody S, Xu Y, Deuchars S, Radford SE, Ranson NA, Frank RAW

Nature communications 14 (2023)

PMID: 37198197

DOI: 10.1038/s41467-023-38495-5

Related EMDB entry:

EMD-18301 EMD-16018

Deposited:

2023-04-14

Released:

2023-09-22

Last modified:

2023-09-22

Imageset size:

40.80 GB

Imageset DOI:

10.6019/EMPIAR-11509

Experimental metadata:

Download xml json

Contains:

tilt series

Image Sets

1. Summed, unaligned tilt series

Category:

tilt series

Image format:

MRC

No. of images or tilt series:

Image size:

(3710, 3838)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(3.421, 3.421)

Details:

Summed, unaligned tilt series from 23 tomograms, -60 to +60˚, 2˚ increments, 85.8˚ microscope rotation angle (hand unknown), ~1 e-/Å2 dose per tilt.
Corresponding CryoCLEM images are also supplied

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Citations

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles

Kim K, Li H, Clarke OB. (2025)

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Krentzel D, Elphick M, Domart MC, Peddie CJ, Laine RF, Shand C, Henriques R, Collinson LM, Jones ML. (2025)

CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy.

Arora S, Pan SH, Kumar S, Singh SK, Chauhan U, Alhalabi W, Arya V, Alsulami BS, Hsu CH, Chui KT, Gupta BB. (2025)

PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning.

Costa-Gomes B, Greer J, Juraschko N, Parkhurst J, Mirecka J, Famili M, Rangel-Smith C, Strickson O, Lowe A, Basham M, Burnley T. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

Laser flash melting cryo-EM samples to overcome preferred orientation.

Straub MS, Harder OF, Mowry NJ, Barrass SV, Hruby J, Drabbels M, Lorenz UJ. (2025)

In situ structure determination of conformationally flexible targets using nextPYP.

Liu HF, Zhou Y, Huang Q, Martin J, Bartesaghi A. (2025)

EMICSS: added-value annotations for EMDB entries.

Duraisamy AK, Fonseca N, Kleywegt GJ, Patwardhan A, Morris KL. (2025)

Global conformations of <i>Pichia pastoris</i> complex I are distinguished by the binding of a unique interdomain bridging subunit.

Lee CS, Grba DN, Wright JJ, Ivanov BS, Hirst J. (2025)

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification

Williams HM, Curtis WA, Haubner M, Hruby J, Drabbels M, Lorenz UJ. (2025)

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