EMPIAR-11470 - Unaligned cryo-EM micrographs of HCN4 channel bound to Ivabradine [31670 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-11470

Unaligned cryo-EM micrographs of HCN4 channel bound to Ivabradine [31670 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

Structural determinants of ivabradine block of the open pore of HCN4

Saponaro A, Krumbach JH, Chaves-Sanjuan A, Sharifzadeh AS, Porro A, Castelli R, Hamacher K, Bolognesi M, DiFrancesco D, Clarke OB, Thiel G, Moroni A

Proceedings of the National Academy of Sciences of the United States of America 121 (2024)

PMID: 38917012

DOI: 10.1073/pnas.2402259121

Related EMDB entry:

EMD-16860

Deposited:

2023-03-16

Released:

2025-03-21

Last modified:

2025-03-21

Imageset size:

9.34 TB

Imageset DOI:

10.6019/EMPIAR-11470

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of HCN4 channel bound to Ivabradine

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

31670

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.42, 0.42)

Details:

The micrographs comes from two different data collection sessions and they are divided in two separated folders, each containing their own gain-reference file. The micrographs were recorded in super-resolution mode.

Files:

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Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

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