EMPIAR-11448 - 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) [3916 multi-frame micrographs composed of 57 frames each in TIFF format]

EMPIAR-11448

5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) [3916 multi-frame micrographs composed of 57 frames each in TIFF format]

Publication:

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL

Neuron 110 (2022) 3154-3167.e7

PMID: 36087581

DOI: 10.1016/j.neuron.2022.08.006

Related EMDB entry:

EMD-25402

Deposited:

2022-07-02

Released:

2024-02-09

Last modified:

2024-02-09

Imageset size:

2.05 TB

Imageset DOI:

10.6019/EMPIAR-11448

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3916

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.43385, 0.43385)

Details:

The micrographs are the average of 57 raw movie frames accumulating 61.11 electron per squared Angstrom in a 2.5 sec exposure.

Files:

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Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.

Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

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