EMPIAR-10380
Single particle cryo electron microscopy of the human serotonin transporter bound with paroxetine and in complex with 8B6 Fab [multiple data sets in TIFF and MRC formats]
Publication:

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E

eLife 9 (2020)

PMID: 32618269

Related EMDB entry:
Deposited:
2020-02-10
Released:
2020-07-01
Last modified:
2022-01-14
Imageset size:
2.66 TB
Imageset DOI:
Experimental metadata:
Download xml json
Contains:
  • micrographs - multiframe
  • micrographs - single frame
  • picked particles - multiframe - unprocessed
1. Dataset 1 unaligned multi-frame micrographs of SERT-8B6 Fab complex bound to paroxetine
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
2557
Image size:
(11520, 8184)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.324, 0.324)
Details:
Multiframe movies contain 40 raw frames with a total dose of 54 e-/A^2.
Files:
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2. Dataset 2 unaligned multi-frame micrographs of SERT-8B6 Fab complex bound to paroxetine
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
4613
Image size:
(11520, 8184)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.324, 0.324)
Details:
Multiframe movies contain 40 raw frames with a total dose of 60 e-/A^2.
Files:
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3. Aligned micrographs of the SERT-8B6 paroxetine Fab complex bound to paroxetine
Category:
micrographs - single frame
Image format:
MRC
No. of images or tilt series:
7170
Image size:
(5760, 4092)
Pixel type:
32 BIT FLOAT
Pixel spacing:
(0.648, 0.648)
Details:
Aligned micrographs. Picked particles also follow pattern: data/coord/g3_F_paro_05702_mc_DW_coord.star
Files:
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4. Particle stack of the SERT-8B6 paroxetine Fab complex bound to paroxetine
Category:
picked particles - multiframe - unprocessed
Image format:
MRC
No. of images or tilt series:
420373
Image size:
(400, 400)
Pixel type:
32 BIT FLOAT
Pixel spacing:
(0.648, 0.648)
Details:
Final refined particle stack and coordinates. Picked particles also follow pattern: data/coord/g3_F_paro_05702_mc_DW_coord.star
Files:
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Files:
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