EMPIAR-11302 - Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG [3890 multi-frame micrographs composed of 48 frames each in TIFF format]

EMPIAR-11302

Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG [3890 multi-frame micrographs composed of 48 frames each in TIFF format]

Publication:

Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro

Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Diskson DW, Vinters HV, Eisenberg DS

Nature communications 13 (2022) 5451-12

PMID: 36114178

DOI: 10.1038/s41467-022-32951-4

Related EMDB entry:

EMD-26664

Deposited:

2022-11-10

Released:

2022-11-21

Last modified:

2022-11-21

Imageset size:

3.74 TB

Imageset DOI:

10.6019/EMPIAR-11302

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame movies

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

3890

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.539, 0.539)

Details:

Dosage is 1.2 e/A^2. Gain and dark corrected frames.

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Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

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