EMPIAR-11295 - Cryo-EM movies of the human α1β3γ2 GABA<sub>A</sub> receptor in a lipid bilayer bound to diazepam and GABA [1472 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-11295

Cryo-EM movies of the human α1β3γ2 GABA_A receptor in a lipid bilayer bound to diazepam and GABA [1472 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

GABA_A receptor signalling mechanisms revealed by structural pharmacology

Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR

Nature 565 (2019) 454-459

PMID: 30602790

DOI: 10.1038/s41586-018-0832-5

Related EMDB entry:

EMD-0283

Deposited:

2022-06-30

Released:

2022-11-15

Last modified:

2023-01-20

Imageset size:

2.03 TB

Imageset DOI:

10.6019/EMPIAR-11295

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Cryo-EM movies of the human α1β3γ2 GABAA receptor in a lipid bilayer bound to diazepam and GABA

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

1472

Image size:

(3838, 3710)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.89, 0.89)

Details:

---

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Citations

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Kim K, Li H, Clarke OB. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

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In situ structure determination of conformationally flexible targets using nextPYP.

Liu HF, Zhou Y, Huang Q, Martin J, Bartesaghi A. (2025)

CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles.

Zhang H, Zheng D, Wu Q, Yan N, Peng H, Hu Q, Peng Y, Yan Z, Shi Z, Bao C, Hu M. (2025)

Few-shot learning for non-vitrified ice segmentation.

Vivas-Lago A, Castaño-Díez D. (2025)

Automated removal of corrupted tilts in cryo-electron tomography.

Majtner T, Turoňová B. (2025)

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries.

Felix J, De Munck S, Bazan JF, Savvides SN. (2025)

Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE.

Van CTS, Reboul CF, Caesar JJE, Meana-Pañeda R, Lountos GT, Deme JC, Bryant OJ, Johnson S, Piczak CT, Valkov E, Lea SM, Elmlund H. (2025)

Cryo-EM Structure Reconstruction by Gaussian Splatting: Pushing the Resolution to Extreme

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2025)

Molecular exaptation by the integrin αI domain.

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