EMPIAR-10374
CryoEM reconstruction of human ABCG2 transporter with inhibitor MZ29 and 5D3-Fab [multiple data sets in MRC and MRCS formats]
Publication:

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP

Nature structural & molecular biology 25 (2018) 333-340

PMID: 29610494

Related EMDB entry:
Deposited:
2020-02-12
Released:
2020-07-15
Last modified:
2020-07-15
Imageset size:
1.91 TB
Imageset DOI:
Experimental metadata:
Download xml json

Compressed by PDBj:

Image formats and pixel types shown below are those of the original, non-compressed files.

MRC movies (Movies/*/*.mrc) in this entry were compressed by bzip2 (pbzip2)
by EMPIAR Japan to save space and bandwidth.

Some programs (e.g. RELION >= 4.0.1 and CryoSPARC) can process compressed movies without explicit
decompression. For other programs, movies have to be decompressed beforehand. In this case,
you might want to convert decompressed MRC movies into TIFF to save your local storage.

Original size:   5,692,815,491 kilobytes
Compressed size: 1,703,873,146 kilobytes
Contains:
  • micrographs - multiframe
  • picked particles - single frame - processed
1. Unaligned super-resolution multi-frame micrographs of MZ-29 inhibitor bound ABCG2-Fab.
Category:
micrographs - multiframe
Image format:
MRC
No. of images or tilt series:
4094
Image size:
(7676, 7420)
Pixel type:
4 BIT INTEGER
Pixel spacing:
(0.42, 0.42)
Details:
Unaligned super-resolution (K2 camera) multi-frame micrographs of MZ-29 inhibitor bound ABCG2-Fab. One movie is made of 50 frames (10sec in total/0.2s per frame, frame dose is 2.0 e/A2).
Files:
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2. Extracted particles and corresponding star file
Category:
picked particles - single frame - processed
Image format:
MRCS
No. of images or tilt series:
587743
Image size:
(384, 384)
Pixel type:
32 BIT FLOAT
Pixel spacing:
(0.84, 0.84)
Details:
All particles picked up with Gautomatch and extracted from all micrographs.
Files:
Loading...
Abe KM, Li G, He Q, Grant T, Lim CJ. (2024)
Fenn KL, Horne JE, Crossley JA, Böhringer N, Horne RJ, Schäberle TF, Calabrese AN, Radford SE, Ranson NA. (2024)
Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)
Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)
Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)