EMPIAR-11093 - Micrographs of IAPP (amylin) amyloid fibrils [1330 micrographs in MRC format]

EMPIAR-11093

Micrographs of IAPP (amylin) amyloid fibrils [1330 micrographs in MRC format]

Publication:

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

Röder C, Kupreichyk T, Gremer L, Schäfer LU, Pothula KR, Ravelli RBG, Willbold D, Hoyer W, Schröder GF

Nature structural & molecular biology 27 (2020) 660-667

PMID: 32541895

DOI: 10.1038/s41594-020-0442-4

Related EMDB entry:

EMD-10669 EMD-10671 EMD-10670

Deposited:

2020-09-11

Released:

2022-07-27

Last modified:

2022-07-27

Imageset size:

83.13 GB

Imageset DOI:

10.6019/EMPIAR-11093

Experimental metadata:

Download xml json

Contains:

micrographs - single frame

Image Sets

1. MotionCor2-aligned single frame of islet amyloid polypeptide fibrils

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

1330

Image size:

(4096, 4096)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.935, 0.935)

Details:

These data are aligned average micrographs collected on a Technai Arctica at 200kV with a Falcon III detector operating in electron counting mode. Applied defocus values ranged from −1 to −2.2 µm. MotionCor2 was used to align 50 dose fractions that were taken with a total electron dose of ~42e-/Å².

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Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

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