EMPIAR-11007 - The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661) [4257 multi-frame micrographs composed of 50 frames each in TIFF format]

EMPIAR-11007

The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661) [4257 multi-frame micrographs composed of 50 frames each in TIFF format]

Publication:

Mechanism of CFTR correction by type I folding correctors

Fiedorczuk K, Chen J

Cell 185 (2021) 158-168

PMID: 34995514

DOI: 10.1016/j.cell.2021.12.009

Related EMDB entry:

EMD-25445

Deposited:

2022-02-16

Released:

2022-05-24

Last modified:

2022-05-24

Imageset size:

2.01 TB

Imageset DOI:

10.6019/EMPIAR-11007

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661)

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

4257

Image size:

(7420, 7676)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.515, 0.515)

Details:

The dataset contains super-resolution, raw, uncorrected movies and gain references that have been flipped and rotated by 90 degrees for use. The super-resolution pixel size is 0.515 Angstrom before binning (1.03 Angstrom after binning)

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Citations

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PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning.

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Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

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Lee CS, Grba DN, Wright JJ, Ivanov BS, Hirst J. (2025)

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