EMPIAR-12657 - CryoEM structural characterization of α-Synuclein Oligomers in complex with PSMa3 peptide [stack of 135393 particles in MRCS format]

EMPIAR-12657

CryoEM structural characterization of α-Synuclein Oligomers in complex with PSMa3 peptide [stack of 135393 particles in MRCS format]

Publication:

A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion

Santos J, Cuellar J, Pallarès I, Byrd EJ, Lends A, Moro F, Abdul-Shukkoor MB, Pujols J, Velasco-Carneros L, Sobott F, Otzen DE, Calabrese AN, Muga A, Pedersen JS, Loquet A, Valpuesta JM, Radford SE, Ventura S

Journal of the American Chemical Society 146 (2024) 12702-12711

PMID: 38683963

DOI: 10.1021/jacs.4c02262

Related EMDB entry:

EMD-16528

Deposited:

2025-03-27

Released:

2025-04-09

Last modified:

2025-04-09

Imageset size:

19.07 GB

Imageset DOI:

10.6019/EMPIAR-12657

Experimental metadata:

Download xml json

Contains:

picked particles - multiframe - processed

Image Sets

1. Particles of a-synuclein oligomers in complex with PSMa3 peptide

Category:

picked particles - multiframe - processed

Image format:

MRCS

No. of images or tilt series:

135393

Image size:

(80, 80)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(2.74, 2.74)

Details:

the original images pixel size was 1.37. These are 2x binned particles.

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Citations

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles

Kim K, Li H, Clarke OB. (2025)

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Krentzel D, Elphick M, Domart MC, Peddie CJ, Laine RF, Shand C, Henriques R, Collinson LM, Jones ML. (2025)

CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy.

Arora S, Pan SH, Kumar S, Singh SK, Chauhan U, Alhalabi W, Arya V, Alsulami BS, Hsu CH, Chui KT, Gupta BB. (2025)

PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning.

Costa-Gomes B, Greer J, Juraschko N, Parkhurst J, Mirecka J, Famili M, Rangel-Smith C, Strickson O, Lowe A, Basham M, Burnley T. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

Laser flash melting cryo-EM samples to overcome preferred orientation.

Straub MS, Harder OF, Mowry NJ, Barrass SV, Hruby J, Drabbels M, Lorenz UJ. (2025)

In situ structure determination of conformationally flexible targets using nextPYP.

Liu HF, Zhou Y, Huang Q, Martin J, Bartesaghi A. (2025)

EMICSS: added-value annotations for EMDB entries.

Duraisamy AK, Fonseca N, Kleywegt GJ, Patwardhan A, Morris KL. (2025)

Global conformations of <i>Pichia pastoris</i> complex I are distinguished by the binding of a unique interdomain bridging subunit.

Lee CS, Grba DN, Wright JJ, Ivanov BS, Hirst J. (2025)

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification

Williams HM, Curtis WA, Haubner M, Hruby J, Drabbels M, Lorenz UJ. (2025)

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