EMPIAR-12657 - CryoEM structural characterization of α-Synuclein Oligomers in complex with PSMa3 peptide [stack of 135393 particles in MRCS format]

EMPIAR-12657

CryoEM structural characterization of α-Synuclein Oligomers in complex with PSMa3 peptide [stack of 135393 particles in MRCS format]

Publication:

A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion

Santos J, Cuellar J, Pallarès I, Byrd EJ, Lends A, Moro F, Abdul-Shukkoor MB, Pujols J, Velasco-Carneros L, Sobott F, Otzen DE, Calabrese AN, Muga A, Pedersen JS, Loquet A, Valpuesta JM, Radford SE, Ventura S

Journal of the American Chemical Society 146 (2024) 12702-12711

PMID: 38683963

DOI: 10.1021/jacs.4c02262

Related EMDB entry:

EMD-16528

Deposited:

2025-03-27

Released:

2025-04-09

Last modified:

2025-04-09

Imageset size:

17.76 GB

Imageset DOI:

10.6019/EMPIAR-12657

Experimental metadata:

Download xml json

Contains:

picked particles - multiframe - processed

Image Sets

1. Particles of a-synuclein oligomers in complex with PSMa3 peptide

Category:

picked particles - multiframe - processed

Image format:

MRCS

No. of images or tilt series:

135393

Image size:

(80, 80)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(2.74, 2.74)

Details:

the original images pixel size was 1.37. These are 2x binned particles.

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Citations

Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing.

Abe KM, Li G, He Q, Grant T, Lim CJ. (2024)

Outer membrane protein assembly mediated by BAM-SurA complexes.

Fenn KL, Horne JE, Crossley JA, Böhringer N, Horne RJ, Schäberle TF, Calabrese AN, Radford SE, Ranson NA. (2024)

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.

Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

See all citations

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