EMPIAR-12044 - Single particle cryo-EM analysis of inhibitor 172 bound cystic fibrosis transmembrane conductance regulator E1371Q mutant [10700 multi-frame micrographs composed of 50 frames each in TIFF format]

EMPIAR-12044

Single particle cryo-EM analysis of inhibitor 172 bound cystic fibrosis transmembrane conductance regulator E1371Q mutant [10700 multi-frame micrographs composed of 50 frames each in TIFF format]

Publication:

Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore

Gao X, Yeh HI, Yang Z, Fan C, Jiang F, Howard RJ, Lindahl E, Kappes JC, Hwang TC

Nature communications 15 (2024)

PMID: 39107303

DOI: 10.1038/s41467-024-50641-1

Related EMDB entry:

EMD-43014

Deposited:

2024-04-17

Released:

2024-08-26

Last modified:

2024-08-26

Imageset size:

6.39 TB

Imageset DOI:

10.6019/EMPIAR-12044

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of inhibitor 172 bound human cystic fibrosis transmembrane conductance regulator E1371Q mutant

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

10700

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

---

Files:

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Citations

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Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

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Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

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