EMPIAR-11930 - CryoEM of Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fibers [7921 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-11930

CryoEM of Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fibers [7921 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method

Rosenberg GM, Abskharon R, Boyer DR, Ge P, Sawaya MR, Eisenberg DS

PNAS nexus 2 (2023)

PMID: 38077690

DOI: 10.1093/pnasnexus/pgad402

Related EMDB entry:

EMD-41198

Deposited:

2024-02-29

Released:

2025-04-10

Last modified:

2025-04-10

Imageset size:

3.54 TB

Imageset DOI:

10.6019/EMPIAR-11930

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Multi-frame micrographs of amyloid fibrils formed by the LCD of TFG with the P285L mutation

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

7921

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

---

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Citations

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Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.

Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

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