EMPIAR-11680 - Single particle cryo-EM dataset of sarkosyl-insoluble fraction from tg-SwDI mouse mouse brain tissue containing amyloid-beta fibrils [25662 multi-frame micrographs composed of 700 frames each in EER format]

EMPIAR-11680

Single particle cryo-EM dataset of sarkosyl-insoluble fraction from tg-SwDI mouse mouse brain tissue containing amyloid-beta fibrils [25662 multi-frame micrographs composed of 700 frames each in EER format]

Publication:

Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Zielinski M, Peralta Reyes FS, Gremer L, Schemmert S, Frieg B, Schäfer LU, Willuweit A, Donner L, Elvers M, Nilsson LNG, Syvänen S, Sehlin D, Ingelsson M, Willbold D, Schröder GF

Nature neuroscience 26 (2023) 2073-2080

PMID: 37973869

DOI: 10.1038/s41593-023-01484-4

Related EMDB entry:

EMD-16959 EMD-16957 EMD-16961

Deposited:

2023-08-04

Released:

2025-07-16

Last modified:

2025-07-16

Imageset size:

11.22 TB

Imageset DOI:

10.6019/EMPIAR-11680

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of amyloid fibrils extracted from the tg-SwDI mouse model

Category:

micrographs - multiframe

Image format:

EER

No. of images or tilt series:

25662

Image size:

(4096, 4096)

Pixel type:

BIT

Pixel spacing:

(0.808, 0.808)

Details:

The files are unaligned multi-frame movies. The data was collected in EER format with 700 camera frames (total dose of 40.1 electrons per squared Angstrom in a 2.91s exposure).

Files:

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Citations

Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing.

Abe KM, Li G, He Q, Grant T, Lim CJ. (2024)

Outer membrane protein assembly mediated by BAM-SurA complexes.

Fenn KL, Horne JE, Crossley JA, Böhringer N, Horne RJ, Schäberle TF, Calabrese AN, Radford SE, Ranson NA. (2024)

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.

Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

See all citations

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