EMPIAR-11301 - Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours [6406 multi-frame micrographs composed of 30 frames each in MRCS format]

EMPIAR-11301

Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours [6406 multi-frame micrographs composed of 30 frames each in MRCS format]

Publication:

Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro

Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Diskson DW, Vinters HV, Eisenberg DS

Nature communications 13 (2022) 5451-12

PMID: 36114178

DOI: 10.1038/s41467-022-32951-4

Related EMDB entry:

EMD-26665

Deposited:

2022-11-10

Released:

2022-11-21

Last modified:

2022-11-21

Imageset size:

1.70 TB

Imageset DOI:

10.6019/EMPIAR-11301

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame movies

Category:

micrographs - multiframe

Image format:

MRCS

No. of images or tilt series:

6406

Image size:

(7676, 7420)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.532, 0.532)

Details:

Total dosage for each movie is 18 e/A^2.

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Citations

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Fenn KL, Horne JE, Crossley JA, Böhringer N, Horne RJ, Schäberle TF, Calabrese AN, Radford SE, Ranson NA. (2024)

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.

Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

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