EMPIAR-10917 - Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the frontal cortex of an individual with pathological aging of amyloid-β 42 filaments [1189 multi-frame micrographs composed of 48 frames each in TIFF format]

EMPIAR-10917

Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the frontal cortex of an individual with pathological aging of amyloid-β 42 filaments [1189 multi-frame micrographs composed of 48 frames each in TIFF format]

Publication:

Cryo-EM structures of amyloid-β 42 filaments from human brains

Yang Y, Arseni D, Zhang WJ, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew S, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SHW, Goedert M

Science (New York, N.Y.) 375 (2022) 167-172

PMID: 35025654

DOI: 10.1126/science.abm7285

Related EMDB entry:

EMD-13809

Deposited:

2022-01-06

Released:

2022-01-24

Last modified:

2023-01-23

Imageset size:

1.01 TB

Imageset DOI:

10.6019/EMPIAR-10917

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame movies

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

1189

Image size:

(5760, 4092)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.73, 0.73)

Details:

The files were written as tiff files by EPU. The pixel size is 0.73 A/px. The dose rate is 1 e/A2/frame. Please use gain-reference.mrc as a gain reference without any rotation or flipping.
pick_coordinates contains start-end coordinates of the manually picked filaments.
Refine102_run_data.star contains STAR file(s) with the metadata of the final refined segments.

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