EMPIAR-10854 - cryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 [5359 multi-frame micrographs composed of 60 frames each in TIFF format]

EMPIAR-10854

cryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 [5359 multi-frame micrographs composed of 60 frames each in TIFF format]

Publication:

Structure, function and pharmacology of human itch GPCRs

Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL

Nature 600 (2021) 170-175

PMID: 34789874

DOI: 10.1038/s41586-021-04126-6

Related EMDB entry:

EMD-24898

Deposited:

2021-10-01

Released:

2021-12-23

Last modified:

2022-01-24

Imageset size:

1.60 TB

Imageset DOI:

10.6019/EMPIAR-10854

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

5359

Image size:

(5760, 4092)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(None, None)

Details:

The micrographs are raw tiff 60 frame movies collected on a 200 keV ThermoFisher Scientific G3 Talos Arctica equipped with a Gatan K3 direct-electron detector (total exposure dose 50.54 e/A^2, 0.91 raw pixel size)

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Citations

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Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch.

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024)

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.

Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. (2024)

The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.

Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. (2024)

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