EMPIAR-10438 - Single-particle cryo-EM of the human CDK-activating kinase in complex with THZ1 [4453 multi-frame micrographs composed of 69 frames each in TIFF format]

EMPIAR-10438

Single-particle cryo-EM of the human CDK-activating kinase in complex with THZ1 [4453 multi-frame micrographs composed of 69 frames each in TIFF format]

Publication:

The cryoelectron microscopy structure of the human CDK-activating kinase

Greber BJ, Perez-Bertoldi JM, Lim K, Iavarone AT, Toso DB, Nogales E

Proceedings of the National Academy of Sciences of the United States of America (2020)

PMID: 32855301

DOI: 10.1073/pnas.2009627117

Related EMDB entry:

EMD-22131

Deposited:

2020-06-11

Released:

2020-09-28

Last modified:

2020-09-28

Imageset size:

2.63 TB

Imageset DOI:

10.6019/EMPIAR-10438

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned movies of human CAK-THZ1

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

4453

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.343, 0.343)

Details:

Unaligned super-resolution electron micrograph movies without gain correction (gain reference is provided). 69 frames per movie with an accumulated exposure of 69 electrons per Angstrom squared.

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Citations

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles

Kim K, Li H, Clarke OB. (2025)

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Krentzel D, Elphick M, Domart MC, Peddie CJ, Laine RF, Shand C, Henriques R, Collinson LM, Jones ML. (2025)

CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy.

Arora S, Pan SH, Kumar S, Singh SK, Chauhan U, Alhalabi W, Arya V, Alsulami BS, Hsu CH, Chui KT, Gupta BB. (2025)

PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning.

Costa-Gomes B, Greer J, Juraschko N, Parkhurst J, Mirecka J, Famili M, Rangel-Smith C, Strickson O, Lowe A, Basham M, Burnley T. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

Laser flash melting cryo-EM samples to overcome preferred orientation.

Straub MS, Harder OF, Mowry NJ, Barrass SV, Hruby J, Drabbels M, Lorenz UJ. (2025)

In situ structure determination of conformationally flexible targets using nextPYP.

Liu HF, Zhou Y, Huang Q, Martin J, Bartesaghi A. (2025)

EMICSS: added-value annotations for EMDB entries.

Duraisamy AK, Fonseca N, Kleywegt GJ, Patwardhan A, Morris KL. (2025)

Global conformations of <i>Pichia pastoris</i> complex I are distinguished by the binding of a unique interdomain bridging subunit.

Lee CS, Grba DN, Wright JJ, Ivanov BS, Hirst J. (2025)

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification

Williams HM, Curtis WA, Haubner M, Hruby J, Drabbels M, Lorenz UJ. (2025)

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