EMPIAR-11704 - ATTRV122I amyloid fibrils from hereditary ATTR amloidosis [2068 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-11704

ATTRV122I amyloid fibrils from hereditary ATTR amloidosis [2068 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis

Steinebrei M, Baur J, Pradhan A, Kupfer N, Wiese S, Hegenbart U, Schönland SO, Schmidt M, Fändrich M

Nature communications 14 (2023)

PMID: 37993462

DOI: 10.1038/s41467-023-43301-3

Related EMDB entry:

EMD-17738

Deposited:

2023-06-29

Released:

2023-12-18

Last modified:

2023-12-18

Imageset size:

644.49 GB

Imageset DOI:

10.6019/EMPIAR-11704

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of ATTRV122I amyloid fibrils

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

2068

Image size:

(None, None)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(1.04, 1.04)

Details:

Krios1 Quantum-K2
Cs 2.7
300kV EFTEM nanpprobe
x130k spot 8 beam size 650nm
c2=50 objective_aperture=100

GIF-K2 counting
10s exposure 40 frames
total dose at the sample 57.70e/A2 --> dose per frame 1.4425
1 pixel = 1.04A
dose rate ~3-4 e/pix/s

defocus range -1.2 to -2.5

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